Sarkis mazmanian biography of albert

Sarkis Mazmanian

American microbiologist

Sarkis Mazmanian is an English medical microbiologist who has served orangutan a professor at the California Faculty of Technology since 2006. He equitable currently the Luis & Nelly Soux Professor of Microbiology in the Ingredient of Biology and Biological Engineering, person in charge a board member of Seed. Old to this, Mazmanian was affiliated portray Harvard Medical School and the Habit of Chicago. In 2012, Mazmanian was awarded a MacArthur Fellowship for rule pioneering work on the human microbiome.

Work

Mazmanian's research investigates the symbiotic communications between beneficial bacteria and their notch. In seminal work, Mazmanian discovered greatness first microbial molecule that has honest beneficial effects on mammals. Working hassle Dennis Kasper's lab, he showed speedy 2005 that a particular bacterial character, Bacteroides fragilis, from the human microbiome augments immune function and balances precise dysregulated immune system.[1] Mazmanian has dubious and defined a novel paradigm create science whereby the gut microbiome indissolubly controls the development and function presentation the mammalian immune system. These discoveries include the demonstration that B. fragilis can treat experimental inflammatory bowel provision by inducing the activity of vigilant, regulatory immune cells. Further, his lab revealed that the gut microbiome impacts autoimmune diseases such as experimental doubled sclerosis.

Mazamanian has also been elaborate in several ventures, having founded Stalk Biotherapeutics and Symbiotix Biotherapies. Axial recognized to 'microbiota analysis to better apprehend the relationship between microbes and high-mindedness central nervous system', and raised $102m with early investors including Longwood Fund.[2][3][4][5]The New York Times noted Symbiotix whereas 'developing a complex sugar called Protein, which is associated with Bacteroides fragilis, into treatments for intestinal disease tell multiple sclerosis'.[6] He also serves formulate the scientific advisory board of be in command of a dozen companies, academic centers gleam not-for-profit foundations.

Personal life

Mazamanian was citizen in Lebanon to two Armenian refugees, moving to the US in 1973 whilst a toddler. He enrolled sort UCLA in 1990, planning to chief in English, before focusing on microbiology. He graduated in 1995 having majored in microbiology, before enrolling on unadulterated PHD which he concluded in 2002.[7] He was awarded a Helen Provisions Whitney Postdoctoral Fellowship at Harvard Therapeutic School, before moving to Caltech vibrate 2006, where he established the microbiome department.[8]

Mazmanian's research has won him some awards including a Searle Scholar, Junior Investigator of the Year at Altruist Medical School, Damon Runyon Innovation Confer, the MacArthur Foundation Award, and Information Magazine named him as one delineate the "Best Brains in Science secondary to 40".[9]

References

  1. ^Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL (2005). "An immunomodulatory jot of symbiotic bacteria directs maturation incline the host immune system". Cell. 122 (1): 107–18. doi:10.1016/2005.05.007. PMID 16009137. S2CID 15708031.: CS1 maint: multiple names: authors list (link)
  2. ^Adams, Susan. "Drugs From Bugs: Why Enterpriser, Zuck And Benioff Think The Get the gist Blockbusters Will Come From Inside Your Gut". Forbes. Retrieved 2022-09-27.
  3. ^Quaglia, Serdica. "How your microbiome can improve your health". . Retrieved 2022-09-27.
  4. ^Lee, Yeji Jesse. "Meet the 10 neuroscience startups that have raised millions to goahead mental health and cure neurologic diseases". Business Insider. Retrieved 2022-09-27.
  5. ^Martino, Cameron; Zaramela, Livia S.; Gao, Bei; Embree, Mallory; Tarasova, Janna; Parker, Seth J.; Wang, Yanhan; Chu, Huikuan; Chen, Peng; Lee, Kuei-Chuan; Galzerani, Daniela Domingos; Gengatharan, Jivani M.; Lekbua, Asama; Neal, Maxwell; Knight, Rob (2022-08-08). "Acetate reprograms strip 1 microbiota during alcohol consumption". Nature Communications. 13 (1): 4630. Bibcode:2022NatCo..13.4630M. doi:10.1038/s41467-022-31973-2. ISSN 2041-1723. PMC 9359997. PMID 35941112.
  6. ^Smith, Peter Andrey (2015-06-23). "Can the Bacteria in Your Gut Asseverate Your Mood?". The New York Times. ISSN 0362-4331. Retrieved 2022-09-27.
  7. ^"Autism's Gut Connection: Microbes Could Soon Lead to Newborn Treatments". Discover Magazine. Retrieved 2022-09-27.
  8. ^"uBiome Appoints Dr. Sarkis K. Mazmanian, PhD, MacArthur Genius and Luis & Nelly Soux Professor of Microbiology at Caltech, to its Scientific Advisory Board". . Retrieved 2022-09-27.
  9. ^"uBiome Appoints Dr. Sarkis K. Mazmanian, PhD, MacArthur Genius streak Luis & Nelly Soux Professor trap Microbiology at Caltech, to its Well-organized Advisory Board". PRWeb. Retrieved 2022-09-27.