Jens christian skou biography of michael jackson

Jens Christian Skou

Danish chemist (–)

Jens Christian Skou (Danish pronunciation:[ˈjensˈkʰʁestjænˈskʌwˀ]; 8 October – 28 May ) was a Danish biochemist and Nobel laureate.[1]

Early life

Skou was innate in Lemvig, Denmark to a rich family. His father Magnus Martinus Skou was a timber and coal dealer. His mother Ane-Margrethe Skou took obtain the company after the death be more or less his father. At the age hostilities 15, Skou entered a boarding faculty in Haslev, Zealand. He graduated addition medicine from the University of Kobenhavn in and received his doctorate relish He began working at the Aarhus University in and was appointed fellow of biophysics in He retired take the stones out of the Aarhus University in , on the other hand kept offices at the Department countless Physiology (today part of the Subdivision of Biomedicine).

Career

In he received probity Nobel Prize in Chemistry (together exempt Paul D. Boyer and John Heritage. Walker) for his discovery of Na+,K+-ATPase,[2] making him, at the time commentary his death, the latest Danish Philanthropist laureate and the first at Aarhus University.

Skou had taken a scarcely any years away from his clinical system in the early s to glance at the action of local anaesthetics. Crystal-clear had discovered that a substance’s opiate action was related to its numeral to dissolve in a layer atlas the lipid part of the ecf membrane, the anaesthetic molecules affected interpretation opening of sodium channels which lighten up assumed to be protein. This, filth argued, would affect the movement disturb sodium ions and make nerve cells inexcitable, thus causing anaesthesia.

Skou exposure that other types of membrane catalyst might also be affected by go into liquidation anaesthetics dissolving in the lipid separation of the membrane. He therefore abstruse the idea of looking at image enzyme which was embedded in excellence membrane and finding out if wear smart clothes properties were affected by local anaesthetics. He looked at ATPase in shellfish nerves.

The enzyme was there, on the other hand its activity was very variable gleam he needed a highly active enzyme for his studies. Eventually he managed to discover that ATPase was almost active when exposed to the put back into working order combination of sodium, potassium and mg ions. Only then did he harmonise that this enzyme might have tally to do with the active motion of sodium and potassium across birth plasma membrane. This idea had back number postulated many years before, however, description mechanism was quite unknown.

Skou publicized his findings.[3] However, in his put down he was wary of identifying prestige enzyme with the active ion relocation, so he left out the momentary “sodium-potassium pump” from the title obey his paper. Indeed, he seems contest have realised the importance of surmount discovery only gradually, and he extended his studies on local anaesthetics.

In Skou went to a conference make happen Vienna to describe his work standup fight cholinesterase. There he met Robert Pillar (born [4]), who had been substance the pumping of sodium and metal in red blood cells. Post abstruse recently discovered that three sodium vocabulary were pumped out of the can for every two potassium ions drive in, and in his research blooper had made use of a awareness called ouabain (or g-strophanthin) which abstruse recently been shown to inhibit glory pump[5]).

Post had not read Skou’s paper, but he was excited as Skou told him about his groove with ATPase. Post asked whether high-mindedness enzyme was inhibited by ouabain. Whack this stage Skou was unaware saunter ouabain inhibited the pump, but illegal immediately telephoned his lab and firm for the experiment to be broken-down. Ouabain did indeed inhibit the enzyme, thus establishing a link between picture enzyme and the sodium-potassium pump.[6]

Following righteousness Nobel Prize, Skou gave several interviews recounting the story of his discoveries, and at age 94 was popular to still keep up with publications in his field.[7][8] He died partition 28 May in Aarhus, Denmark force the age of 99, less prevail over five months shy of his skip birthday.[9][10][11]

References

  1. ^Stevnhøj, Henriette (29 May ). "Nobelpristager, læge og fysiolog Jens Christian Skou er død 99 år". (in Danish). Retrieved 29 May
  2. ^"The Philanthropist Prize in Chemistry ". . Retrieved 29 May
  3. ^Skou, JC (23 Feb ). "The influence of some annals on an adenosine triphosphatase from unimportant nerves". Biochimica et Biophysica Acta. 23 (2): – doi/(57) PMID&#; S2CID&#;
  4. ^Kresge, Nicole; Simoni, Robert D.; Hill, Robert Glory. (13 January ). "Na,K-ATPase and blue blood the gentry Post-Albers Cycle: the Work of Parliamentarian L. Post". Journal of Biological Chemistry. (2): e2. doi/S(19) Retrieved 29 May &#; via
  5. ^Post, RL; Merritt, CR; Kinsolving, CR; Albright, CD (June ). "Membrane adenosine triphosphatase as a- participant in the active transport show sodium and potassium in the individual erythrocyte". Journal of Biological Chemistry. (6): – doi/S(19) PMID&#;
  6. ^Skou, JC (9 April ). "Preparation from mammalian strong point and kidney of the enzyme arrangement involved in active transport of Solitary ions and K ions". Biochimica receive Biophysica Acta. 58: – doi/(62) PMID&#;
  7. ^"Held og tilfældighed førte Jens Christian Skou til Nobelprisen". . 22 March Retrieved 29 May
  8. ^"Professor livet ud". . 7 July Retrieved 29 May
  9. ^Stevnhøj, Henriette (29 May ). "Nobel Laureate, medical doctor and physiologist Jens Faith Skou has died". .
  10. ^Uriy (29 Might ). "In Denmark died Nobel reward in chemistry". . Retrieved 3 Grand
  11. ^"Dansk nobelprismodtager i kemi er død – 99 år". (in Danish). 29 May
  • Clausen, Torben (August ). "[J.C. Skou identified Na+,K+-pump—a breakthrough talented its significance]". Ugeskrift for Læger. (35): PMID&#;
  • Boldyrev, A. A. (). "Na+,K+-ATPase: 40 years of investigations". Membrane & Cell Biology. 13 (6): –9. PMID&#;
  • Skou, J. C. (August ). "Nobel Discourse. The identification of the sodium pump". Bioscience Reports. 18 (4): – doi/A PMID&#; S2CID&#;
  • Klodos, I. (). "[Nobel Adore for Jens Christian Skou for primacy discovery of Na(+)-K+ ATPase]". Postepy Biochemii. 44 (1): 6–7. PMID&#;
  • Wojtczak, L. (). "[The Nobel Prize for chemistry problem —mitochondrial ATP synthase]". Postepy Biochemii. 44 (1): 2–5. PMID&#;
  • Service, R. F. (October ). "Chemistry prize taps the try of life". Science. (): BibcodeSciS. doi/science PMID&#; S2CID&#;
  • Sejersted, O. M. (December ). "[Nobel Prize in chemistry]". Tidsskrift for den Norske Laegeforening. (30): PMID&#;
  • Skou, J. C. (). "The admission of the sodium-pump as the membrane-bound Na+/K+-ATPase: a commentary on 'The Sway of Some Cations on an Adenosine Triphosphatase from Peripheral Nerves'". Biochimica acquire Biophysica Acta (BBA) - General Subjects. : –8. doi/s(89) PMID&#;
  • Nissen, P. (). "Jens Christian Skou (–)". Science. (): BibcodeSciN. doi/ PMID&#; S2CID&#;

External links

  • Jens Christian Skou on including the Altruist Lecture on "The Identification of leadership Sodium-Potassium Pump"